Thursday, August 31, 2006

patterns of malignant pleural mesothelioma

Malignant pleural mesotheliomais known to mimic morphologically a number of diverse reactive and neoplastic conditions. We describe three unusual intraparenchymal growth patterns of malignant mesothelioma seen in a series of 200 malignant pleural mesotheliomas. The diagnostic pitfalls associated with these findings are described and their potential medico-legal implications are highlighted.

The study group comprised 200 malignant pleural mesotheliomas. In each case diagnosis was morphologically confirmed with ancillary immunohistochemistry using a broad panel of both mesothelial and epithelial markers. The patterns of intraparenchymal growth were documented and grouped as: direct subpleural; lymphangitic; and other. The 200 malignant pleural mesotheliomas comprised 118 epithelioid, 57 biphasic and 25 sarcomatoid, subtyped according to the WHO classification. Direct subpleural invasion was seen in 42 cases, lymphangitic spread in 27 cases. Other less well-defined intraparenchymal patterns included three sarcomatoid subtype malignant mesotheliomas exhibiting an intra-alveolar growth pattern mimicking epithelioid haemangioendothelioma. One epithelioid subtype malignant mesothelioma contained an intraparenchymal tumour nodule microscopically comprising lepidic spread of neoplastic cells over maintained alveolar structures mimicking bronchioloalveolar carcinoma. One epithelioid subtype malignant mesothelioma morphologically had areas in which alveoli were distended by discohesive epithelioid neoplastic cells with no interstitial invasion. The appearances mimicked desquamative interstitial pneumonia. Immunohistochemistry played an important role in the definitive diagnosis of each unusual parenchymal tumour deposit. In 126 malignant mesotheliomas no invasion of the subjacent lung parenchyma was identified.
An awareness of the unusual parenchymal growth pattern in malignant mesothelioma is important to prevent misdiagnosis of other entities. In the medico-legal setting, the presence of epithelioid haemangioendothelioma or bronchioloalveolar carcinoma (in the absence of asbestosis) may be deemed to impact upon the patient's anticipated life expectancy and thereby would decrease the compensation settlement.

Saturday, August 26, 2006

Asbestos Lung Cancer Treatment

Mesothelioma is mainly caused due to contact with asbestos, which has zeolite. When inhaled, the asbestos fibers reach the pleural layer of our lungs and damages the mesothelial cells. When consumed, the asbestos fibers get to our abdominal cavity and cause peritoneal mesothelioma that can spread to the other parts of the body.

Mesothelioma (cancer of the mesothelium) is a disease in which cells of the mesothelium become abnormal and divide without control or order. They can invade and damage nearby tissues and organs. Cancer cells can also metastasize (spread) from their original site to other parts of the body. It is a rare disease caused as a result of malignant cancerous cells lining the patient's body cavities such as chest, abdominal region or the area surrounding the heart. This disease is very difficult to assess consistently due to the great variability in time before diagnosis and the rate of progression of malignant mesothelioma.

Even insignificant exposure to asbestos (commonly reported in such work environments as asbestos mills, mines, shipping yards, some older Navy ships or patients homes) is known to result in mesothelioma, which in many cases does not occur for decades after initial exposure to this cancer-causing substance. It is also known that family members of workers exposed to asbestos can contract this disease through exposure to the workers clothing. Smoking greatly increases the risk of contracting mesothelioma. Some of the earliest symptoms of mesothelioma can often be mistaken for less serious illness and are commonly overlooked. Some patients do not show any signs of sickness in the early stages of development of the disease. Most commonly the symptoms include dyspnea, pleuritic pain, lasting cough, fatigue, and weight loss. This disease is more common in men. Most cases of mesothelioma occur 30-45 years after initial exposure to asbestos. Once it develops, this cancer will continue to grow until it is treated. It is very important that the disease is diagnosed and treated as early as possible.

Working with asbestos is the major risk factor for mesothelioma. A history of asbestos exposure at work is reported in about 70 percent to 80 percent of all cases. However, mesothelioma has been reported in some individuals without any known exposure to asbestos. If tiny asbestos particles float in the air, especially during the manufacturing process, they may be inhaled or swallowed, and can cause serious health problems. In addition to mesothelioma, exposure to asbestos increases the risk of lung cancer, asbestosis (a noncancerous, chronic lung ailment), and other cancers, such as those of the larynx and kidney.

Mesothelioma is a malignant disease that can affect the lining of any internal organ. Most often the pleural lining of the lungs and/or the peritoneal lining of the organs in the abdominal cavity are affected. The plural lining of the lungs is affected when harmful amounts of asbestos are inhaled. When symptoms do develop they may include difficulty breathing, chest pain, and a chronic cough

The faster you consult the doctor and get specialized care the better your chances will be of dealing with this hazardous cancer. Please contact our doctor as soon as possible to get more information and cure the disease.

Many cancer treatment options are not very effective in treating mesothelioma. But at our center we provide you the treatment to reduce the disease and free you from the suffering from our specialist with the medication which are natural and no side effects.

Although reported incidence rates have increased in the past 20 years, mesothelioma is still a relatively rare cancer. Mesothelioma occurs more often in men than in women and risk increases with age, but this disease can appear in either men or women at any age.

Smoking does not appear to increase the risk of mesothelioma. However, the combination of smoking and asbestos exposure significantly increases a person's risk of developing cancer of the air passageways in the lung.

People who work with asbestos wear personal protective equipment to lower their risk of exposure.

Treatment for mesothelioma depends on the location of the cancer, the stage of the disease, and the patient's age and general health. Sometimes, these treatments are combined.

Saturday, August 19, 2006

From Miracle Mineral To Mesothelioma Menace

During World War II Asbestos was hailed by many as a miracle mineral. Almost anything could be built or manufactured from this mineral. The building and construction industries used it as an additive to strengthen cement and plastics. Asbestos fibers can be separated into thin threads which do not conduct electricity and are not affected by heat or chemicals.

The four main types of asbestos are: Amosite with brown fibers, Anthophyllite with gray fibers, white Christie, and blue Crocidolite. Chrysotile has curly fibers while the other three have rod like fibers. These fibers break into dust quite easily and drift in the air. They can stick on skin, clothing, and can easily be swallowed or inhaled.

Use of asbestos skyrocketed during World War II. Shipbuilding used asbestos extensively in freighters and support vessels to insulate boilers, steam pipes and hot water pipes. Asbestos became the miracle construction material as it was easily obtained, processed, and transported.

After WWII cars used asbestos in break shoes and clutch pads. Asbestos found its way into residential and industrial building materials, water supply, sewage materials, ceiling and floor tiles, and vermiculite garden materials to name a few products.

In the 1970's the U.S Consumer Product Safety Commission banned the use of asbestos in several products that could release asbestos fibers into the environment during use, following the discoveries of the health dangers of asbestos dust inhalation. Regulations governing the use of asbestos and concern of public opinion since 1970 have created a significant drop in the use of asbestos in the United States.

In 1989 all new uses of asbestos were banned by the Environmental Protection Agency while any old uses before that year were still permitted. The EPA suggested that schools inspect for damaged asbestos and eliminate any exposure or enclose it in protective barriers. Vermiculite, widely used in horticulture, became a concern of the EPA that recommended outdoor use, limiting the amount of dust used, and keeping vermiculite damp.

Asbestos may create serious health hazards such as coughing, lung damage, shortness of breath, and lung cancer. Most people do not become sick in the early stages of development, but usually need continued exposure, often on jobs such as mining, milling, manufacturing asbestos products, and building construction. Firemen, demolition workers, drywall removers, and any other workers in trades that involve destruction of buildings, ships, and automobiles are also exposed to the hazards and risks of asbestos.

Over a period of years continual exposure to asbestos can cause very serious health problems, such as mesothelioma. Mesothelioma is a rare type of carcinoma of the membrane that lines numerous cavities of the body, including the lungs, abdomen and heart, and has been associated with exposure to asbestos dust. In mesothelioma, the cells of the mesothelioma metastasize and damage adjacent organs and tissues.

Risk of developing mesothelioma takes a long period of time, often as long as twenty-five or thirty-five years before full blown symptoms appear. Not all workers who have been exposed will develop diseases caused by asbestos, but workers who have been exposed to it may bring fibers on their clothing, hair, shoes, and skin home to their families. To circumvent this risk, most industries require workers to bathe and change their clothing before they leave work.

Many studies have been conducted involving the risks of diseases caused by exposure to asbestos. The results of one such study involving the risks of smoking and exposure to asbestos proved extremely hazardous.

For further information on asbestos, such as risks, research, lawsuits and disease support groups visit:
http://www.asbestos-headquarters.com

About the Author
Grant Davis, is a freelance writer and has worked in a variety of fields, including teaching. Feel free to use the above article as long as it is reprinted in its entirety.

Wednesday, August 09, 2006

What Are The Four Stages of Mesothelioma Cancer?

One rare form of cancer is called Mesothelioma, a malignant tumor in the mesothelial tissues of the lungs and the abdomen, arising from the inhalation of asbestos. Its rarity is one of the reasons why a lot of people are not aware of this kind of fatal disease. In fact, many people die of Mesothelioma undiagnosed. Although there is now a growing awareness of the hazards of asbestos to health, still many have not heard of Mesothelioma and thus, have not understood its nature, cause, signs and treatment. Even some physicians find it hard to detect Mesothelioma because its symptoms are akin to other diseases like lung cancer and pneumonia. Furthermore, it takes decades for a patient who was exposed to asbestos to develop Mesothelioma -- fifty years, at most.

Being unaware of Mesothelioma poses higher risks since it deters diagnosis and treatment. A person undergoing treatment must know the different stages of the cancer or the extent of the disease. Chances of recovering from Mesothelioma and the kind of treatment depend on the stage of the illness. There are basically two staging systems used for Pleural Mesothelioma (lungs): TNM system and Brighan system. These staging systems are also used in other kinds of cancers; however, the first is commonly used. There is no established method in determining the stage of the Peritoneal Mesothelioma cancer (abdominal) so the TNM system is used.

There are three variables in the TNM system: tumor, lymph nodes and metastasis. In the earliest stage of Mesothelioma, stage I, the malignant Mesothelioma cells start to grow and multiply only one layer of the pleura. The pleura is the membrane that encloses the lungs and lines the wall of the chest cavity. However, there are some instances wherein the pericardium (membrane that covers the heart) and diaphragm cover are already affected. In this case, the cancer patient is still in stage I Mesothelioma.

In the second stage, the two layers of the pleura are already affected by Mesothelioma. Take note, however, that in this stage, only one side of the body is affected. Normally, the pleura produces only small amount of lubricating fluid that allows easy expanding and contracting of the lungs. The excess fluid is absorbed by the blood and the lymph vessels so there's a balance between the amount of fluid produced and removed. During the second stage Mesothelioma, fluid starts to build up between the membrane of the lungs and the membrane of the chest wall, resulting to pleural effusion. The increase in the volume of fluid produced causes shortness of breath and chest pain. Other Mesothelioma cancer patients experience dry and persistent cough. Diagnosis of the pleural effusion is achieved through a chest x-ray.

Stage III Mesothelioma means that the malignant cells have already spread to the chest wall, esophagus and the lymph nodes on one part of the chest. The patient may suffer severe pain near the parts affected. When not treated immediately or when the Mesothelioma patient doesn't respond well to medication, the cancer may advance to the fourth stage. The fourth stage Mesothelioma is formidable since at this stage the Mesothelioma cells have penetrated into the bloodstream and other organs in the body like the liver, the bones and the brain. The lymph nodes on the other side of the chest may also be affected by Mesothelioma in stage IV.

Brighan staging system, on the other hand, determines whether the Mesothelioma can be surgically removed or not and whether the lymph nodes are affected or not. In stage I Mesothelioma, the lymph nodes are not yet affected and the patient can still recover through surgery. In stage II, surgery can still be executed but some lymph nodes have already been infiltrated by the cancer cells. In stage III, the heart and chest wall are already affected; thus, surgery is no longer advisable. The lymph nodes in this stage, however, may or may not be affected. In the final stage, stage IV Mesothelioma, cancer cells have already gone to the bloodstream and other parts of the body like the heart, brain, bone and liver. In most cases, a patient who has reached stage IV Mesothelioma only has four to twenty-four months to live.

About the Author
David Arnold Livingston is a believer in gaining knowledge around Health issues and recommends, as a resource: http://www.newmesothelioma.com/Mesothelioma Cancer/

Sunday, August 06, 2006

The cancer of the mesothelial cells

The diseased defined
Mesothelium is the protective tissue that covers the chest cavity, abdominal cavity and the cavity around the heart and also produces a special lubricating fluid that allows the internal organs of the body to move around. Malignant Mesothelioma can be defined as the cancer of the mesothelial cells which become abnormal and start dividing without any order. Majority of the mesothelioma patients have a prior history of exposure to asbestos.

Types of malignant Mesothelioma

Malignant Mesothelioma or simply Mesothelioma can be divided into 3 main types namely - Epithelioid - Sarcomatoid - Mixed/biphasic Of these,
Epithelioid is the most common (50% to 70% cases) and stands the best chance of recovery. Sarcomatoid type is seen in 7% to 20% cases whereas mixed/biphasic type is seen in 20% to 35% cases.

Approximately, ¾ of the total cases of Mesothelioma originates in the chest cavity (pleura) and is known as pleural mesothelioma. The cancer affecting the lining of the abdomen (peritoneum) is called the peritoneal mesothelioma and that affecting the "sac like" space around the heart (pericardial cavity) is called the pericardial mesothelioma. Mesothelioma at times also affects the covering layer of the testicles. However, the last two types of cases are quite rare.

Diagnosis of malignant Mesothelioma

The tumors of the mesothelium can either be benign (non cancerous) or malignant (cancerous). So whenever there are symptoms like shortness of breath, pain in chest/abdomen or swelling in the abdomen, you should consult your doctor immediately. After the initial X-rays and scans, the doctor may look inside the chest cavity (in case of pleural tumor) with an instrument called thoracoscope and the test is called thoracoscopy. In case of tumor in peritoneum the doctor may go for peritoneoscopy with the help of a tool called peritoneoscope. Finally, if the abnormal tissue is found then a biopsy is done, whereby a piece of the unnatural tissue is cut out and placed under microscope for examination.

After the confirmed diagnosis of Mesothelioma it is also essential to ascertain its stages i.e. whether it is in localized stage or in advanced stage. In the localized stage, the cancer is found in the lining of the chest cavity or in the diaphragm or the lung. Advanced malignant Mesothelioma can again be divided into 3 stages namely stage II, III and IV. In stage II, the cancer spreads beyond the chest lining to lymph nodes and in stage III it spreads into chest wall, center of the chest, heart, through the diaphragm or abdominal lining, etc. The final or the fourth stage is the one in which the cancer has already spread to distant organs.

Treatment

Depending on the stage of the cancer, its location and the health, age and medical history of the patient, 3 types of treatments are mated out to malignant Mesothelioma patients - surgery (to remove the tumor), radiation therapy (application of high energy rays) and chemotherapy (usage of combination of drugs). This apart, if there is any accumulation of fluid in the chest or abdomen, then the doctor needs to drain it out and the process is regarded as thoracentesis and paracentesis respectively. So be aware of the disease, such that you can prevent it at the very onset.

About the Author
Fred Lindell is a successful writer and publisher of health related issues, for more informative articles go to http://www.mesotheliomaplaza.com